Influence of Di erent Sieving Methods on Estimation of Sand Size Parameters

Sieving is one of the most used operational methods to determine sand size parameters which are essential to analyze coastal dynamics. However, the influence of hand versus mechanical shaking methods has not yet been studied. Herein, samples were taken from inside the hopper of a trailing suction dredger and sieved by hand with sieves of 10 and 20 cm diameters on board the dredger. Afterwards, these same samples were sieved with a mechanical shaker in the laboratory on land. The results showed di erences for the main size parameters D50, standard deviation, skewness, and kurtosis. Amongst the main results, it should be noted that the highest values for D50 and kurtosis were given by the small sieves method. On the other hand, the lowest values were given by the mechanical shaker method in the laboratory. Furthermore, standard deviation and skewness did not seem to be a ected by the sieving method which means that all the grainsize distribution was shifted but the shape remained unchanged. The few samples that do not follow these patterns have a higher percentage of shells. Finally and definitely, the small sieves should be rejected as a sieving method aboard

¿Cambia mucho el tamaño de grano obtenido mediante tamizado manual frente al mecánico?

Los procesos erosivos en el litoral, junto con la importancia económica del turismo (Houston, 2008), hacen que las realimentaciones periódicas de nuestras playas sean sumamente frecuentes. Y el tamaño de la arena es uno de los más importantes parámetros a la hora proyectar este tipo de obras. La media o la desviación típica del tamaño de grano son imprescindibles para comprobar si la arena de préstamo (terrestre o sumergida) es adecuada para sustituir a la transportada previamente por el mar (Pranzini et al., 2018). Además, el conocimiento de la distribución granulométrica del sedimento hace posible prever la reacción del perfil transversal ante una tormenta (Larson y Kraus, 1991), o calcular la cantidad necesaria de arena para abordar una regeneración (USACE, 2002). Por otra parte, a la hora de tomar decisiones sobre la zona de vertido de una cántara llena de arena, el gestor precisa conocer los parámetros antes mencionados de manera casi inmediata. Eso significa que los análisis del sedimento deben efectuarse a bordo de la draga, mientras se desplaza de la zona de préstamo hacia la costa a regenerar. Sin embargo, debido a la habitual escasez de espacio, a la ausencia de un laboratorio adecuado y al no siempre fiable suministro eléctrico, los tamizados deben hacerse a mano. Ya se ha estudiado la influencia del tiempo de tamizado a la hora de analizar la distribución granulométrica de una arena de playa o de duna (Roman-Sierra et al., 2013). Sin embargo, hasta este momento no se ha analizado la posible diferencia en la media y la desviación típica de una arena tamizada de manera manual a bordo de una draga frente a una tamizadora mecánica en un laboratorio en tierra. Asímismo, para ahorrar espacio y esfuerzo físico, a bordo de la draga suelen usarse tamices de 10 cm de diámetro frente a los más habituales de 20 cm en laboratorio. Para dar respuesta a estas preguntas, se aprovechó una regeneración efectuada en Cádiz en el año 2017 para efectuar una serie de pruebas a bordo de la draga Njord. Los extrapolables y más que útiles resultados, así como la influencia y consecuencias que tienen las diferencias observadas en la dirección de obras de regeneración de playas, se expondrán durante la presentación oral

Reliability-based leading edge erosion maintenance strategy selection framework

Leading edge erosion has become one of the most prevailing failure modes of wind turbines. Its effects can evolve from an aerodynamic modification of the properties of the blade to a potential structural failure of the leading edge. The first produces a reduction of energy production and the second can produce a catastrophic failure of the blade. Considering the uncertainties and constraints involved in the design of optimal operation and maintenance (O&M) strategies for offshore assets and the influence of site-specific parameters on the dynamics of this particular failure mode, the task becomes complex. In this study, a framework to evaluate the influence of different maintenance strategies considering uncertainties in weather, material behaviour and repair success is presented. Monte Carlo Simulation (MCS) is used alongside a computational framework for Leading Edge Erosion (LEE) degradation to evaluate the lifetime cost distribution and probability of failure of the chosen maintenance strategies. The use of the framework is demonstrated in a case study considering a 5-MW offshore wind turbine located in the north of Germany. The influence of the modification of the maintenance interval or time between repairs and the comparison with maintenance activities executed only during months with milder weather is analysed in terms of cost and reliability. A Pareto front plot considering the probability of failure and the median of the cost is used to jointly compare strategies considering both aspects to provide a tool for risk-informed maintenance selection. Finally, the potential benefits of condition-based maintenance and autonomous decision-making systems are discussed. The case of study shows the benefits of repairs during summer months and the importance of the relation risk/O&M cost for different maintenance strategies

A cross-sectoral review of the current and potential maintenance strategies for composite structures

The interest in the use of composite materials in thin-walled structures has grown over the last decades due to their well-known superior mechanical performance and reduced weight when compared with traditional materials. Notwithstanding, composite structures are susceptible to damage during manufacturing and to fatigue degradation during service, which grants inspection and maintenance strategies outstanding importance in the duty of mitigating premature failures and reducing whole life cycle costs. This paper aims to provide a cross-sectoral view of the current and potential maintenance strategies that are drawing the attention of the different industries and researchers by reviewing the current use and limitations of composites structures, the impact of maintenance in the whole-life cycle of the composite structures, the health and condition monitoring techniques applied, and the benefits and limitations of the currently used and potential maintenance strategies. Finally, the health and condition monitoring techniques and maintenance approaches used by the different industries are contrasted to identify trends and divergences and suggest research gaps and industrial opportunities

The Illumination and Growth of CRL 2688: An Analysis of New & Archival HST Observations

We present four-color images of CRL 2688 obtained in 2009 using the Wide-Field Camera 3 on HST. The F606W image is compared with archival images in very similar filters to monitor the proper motions of nebular structure. We find that the bright N-S lobes have expanded uniformly by 2.5% and that the ensemble of rings has translated radially by 0.07 in 6.65 y. The rings were ejected every 100y for ~4 millennia until the lobes formed 250y ago. Starlight scattered from the edges of the dark E-W dust lane is coincident with extant H2 images and leading tips of eight pairs of CO outflows. We interpret this as evidence that fingers lie within geometrically opposite cones of opening angles {\approx} 30{\circ} like those in CRL618. By combining our results of the rings with 12CO absorption from the extended AGB wind we ascertain that the rings were ejected at ~18 km s-1 with very little variation and that the distance to CRL2688, v_{exp}$/${\dot\theta}_exp$, is 300 - 350 pc. Our 2009 imaging program included filters that span 0.6 to 1.6{\mu}m. We constructed a two-dimensional dust scattering model of stellar radiation through CRL2688 that successfully reproduces the details of the nebular geometry, its integrated spectral energy distribution, and nearly all of its color variations. The model implies that the optical opacity of the lobes >~ 1, the dust particle density in the rings decreases as radius^{-3} and that the mass and momentum of the AGB winds and their rings have increased over time.Comment: (51 pages, 6 figures; accepted by ApJ

Efficacy of ATR inhibitors as single agents in Ewing sarcoma

Ewing sarcomas (ES) are pediatric bone tumors that arise from a driver translocation, most frequently EWS/FLI1. Current ES treatment involves DNA damaging agents, yet the basis for the sensitivity to these therapies remains unknown. Oncogene-induced replication stress (RS) is a known source of endogenous DNA damage in cancer, which is suppressed by ATR and CHK1 kinases. We here show that ES suffer from high endogenous levels of RS, rendering them particularly dependent on the ATR pathway. Accordingly, two independent ATR inhibitors show in vitro toxicity in ES cell lines as well as in vivo efficacy in ES xenografts as single agents. Expression of EWS/FLI1 or EWS/ERG oncogenic translocations sensitizes non-ES cells to ATR inhibitors. Our data shed light onto the sensitivity of ES to genotoxic agents, and identify ATR inhibitors as a potential therapy for Ewing Sarcomas.We would want to thank Enrique de Alava for providing ES lines. Work in O.F. laboratory was supported by Fundación Botín, by Banco Santander through its Santander Universities Global Division and by grants from MINECO (SAF2014-57791-REDC and SAF2014-59498-R), Fundació La Marato de TV3, Howard Hughes Medical Institute and the European Research Council (ERC-617840). The A.N. laboratory was supported by the Intramural Research Program of the NIH, the National Cancer Institute, the Center for Cancer Research, an Ellison Medical Foundation Senior Scholar in Aging, and the Alex Lemonade Stand Foundation Award. J.A. laboratory is supported by Asociación Pablo Ugarte, ASION-La Hucha de Tomás, Fundación La Sonrisa de Alex and Instituto de Salud Carlos III (PI12/00816 and Spanish Cancer Network RTICC RD12/0036/0027). A.L. laboratory was supported by the Danish National Research Foundation (DNRF115), Danish Council for Independent Research (Sapere Aude, DFF-Starting Grant 2014) and Danish Cancer Society (KBVU-2014).S

Plan de responsabilidad social para la mejora de la compañía Alkosto

Anexo A E-Book de ética para la empresa Alkosto Link : https://editor-storage.reedsy.com/books/135368/exports/success/9355e084-0fb9- 4e34-9b07-28b4fe345e33/202004092354-codigo-de-etica-alkosto.zip Anexo B Diagnostico por observaciónLa empresa seleccionada es una cadena de tiendas en Colombia llamada Alkosto, se caracteriza por ser líder en el sector comercial compitiendo con sus precios bajos, además de comercializar todo tipo de elementos básicos para la satisfacción de una gran variedad de necesidades, por esto vemos una gran oportunidad en expandirnos enfocándonos para el año 2022 en tener mayor presencia a nivel nacional llevando a cada uno de nuestros clientes la mejor experiencia de compra para así fidelizarlos, esto iniciando desde varias de nuestras estrategias de marketing interno y externo, donde deseamos involucrar nuestros clientes y a su vez mejorar nuestra visibilidad mediante la potencialización de marketing digital y redes sociales que a su vez nos ayudara a disminuir publicidad física que genera desechos e impacto ambiental siendo eficaces en nuestro proceso de responsabilidad social, adicional buscamos generar inclusión y reconociendo a todas las personas que interactúen de manera directa o indirecta con la compañía impulsando una mejor calidad de vida, en aspectos económicos y ambientales mediante planes de acción que nos lleven a impactar positivamente y cumpliendo protocolos establecidos para nuestra excelencia, igualmente siempre enfocándonos en incentivar y organizar nuestro personal mediante las políticas de la compañía y cumplimiento estricto de normas para garantizar la calidad de nuestros productos, el buen funcionamiento de todos los almacenes y generando valores corporativos al personal encargado en todas las áreas, para alcanzar la excelencia en conjunto como compañía y transmitirla mediante la prestación de nuestros servicios logrando la satisfacción del cliente.The selected company is a chain of stores in Colombia called Alkosto, it is characterized by being a leader in the commercial sector competing with its low prices, in addition to marketing all kinds of basic elements to satisfy a wide variety of needs, for this we see a great opportunity to expand by focusing by 2022 on having a greater presence at the national level, bringing to each of our clients the best shopping experience in order to retain them, this starting from several of our internal and external marketing strategies, where we want to involve our clients and in turn improve our visibility through the enhancement of digital marketing and social networks that in turn will help us to reduce physical advertising that generates waste and environmental impact, being effective in our process of social responsibility, additionally we seek to generate inclusion and recognizing all people they interact man was direct or indirect with the company promoting a better quality of life, in economic and environmental aspects through action plans that lead us to positively impact and complying with established protocols for our excellence, also always focusing on incentivizing and organizing our personnel through the policies of the company and strict compliance with standards to guarantee the quality of our products, the proper functioning of all warehouses and generating corporate values for the personnel in charge in all areas, to achieve overall excellence as a company and transmit it through the provision of our services achieving customer satisfaction

Insights into the mechanism of activation of the phosphorylation-independent response regulator NblR. Role of residues Cys69 and Cys96

Cyanobacteria respond to environmental stress conditions by adjusting their photosynthesis machinery. In Synechococcus sp. PCC 7942, phycobilisome degradation and other acclimation responses after nutrient or high light stress require activation by the phosphorylation-independent response regulator NblR. Structural modelling of its receiver domain suggested a role for Cys69 and Cys96 on activation of NblR. Here, we investigate this hypothesis by engineering Cys to Ala substitutions. In vivo and in vitro analyses indicated that mutations Cys69Ala and/or Cys96Ala have a minor impact on NblR function, structure, size, or oligomerization state of the protein, and that Cys69 and Cys96 do not seem to form disulphide bridges. Our results argue against the predicted involvement of Cys69 and Cys96 on NblR activation by redox sensing.This work was supported by the Spanish Ministerio de Ciencia e Innovación (grants BFU2009-07371 to A.C., BIO2009-10872 and BIO2010-15424 to A.M. and SAF2008-05742-C02-01 and CSD2008-00005 to J.L.N.) and the Generalitat Valenciana (grants ACOMP2006/083 and ACOMP2011/211 to A.C., ACOMP2010/114 and ACOMP2011/113 to J.L.N.). M.L. López-Redondo was a fellow of the Fundación Mutua Madrileña Automovilística

Daptomycin plus Fosfomycin versus Daptomycin Alone for Methicillin-Resistant Staphylococcus 2 aureus Bacteremia and Endocarditis. A Randomized Clinical Trial

Background We aimed to determine whether daptomycin plus fosfomycin provides higher treatment success than daptomycin alone for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and endocarditis. Methods A randomized (1:1) phase 3 superiority, open-label, and parallel group clinical trial of adult inpatients with MRSA bacteremia was conducted at 18 Spanish hospitals. Patients were randomly assigned to receive either 10 mg/kg of daptomycin intravenously daily plus 2 g of fosfomycin intravenously every 6 hours, or 10 mg/kg of daptomycin intravenously daily. Primary endpoint was treatment success 6 weeks after the end of therapy. Results Of 167 patients randomized, 155 completed the trial and were assessed for the primary endpoint. Treatment success at 6 weeks after the end of therapy was achieved in 40 of 74 patients who received daptomycin plus fosfomycin and in 34 of 81 patients who were given daptomycin alone (54.1% vs 42.0%; relative risk, 1.29 [95% confidence interval, .93-1.8]; P = .135). At 6 weeks, daptomycin plus fosfomycin was associated with lower microbiologic failure (0 vs 9 patients; P = .003) and lower complicated bacteremia (16.2% vs 32.1%; P = .022). Adverse events leading to treatment discontinuation occurred in 13 of 74 patients (17.6%) receiving daptomycin plus fosfomycin, and in 4 of 81 patients (4.9%) receiving daptomycin alone (P = .018). Conclusions Daptomycin plus fosfomycin provided 12% higher rate of treatment success than daptomycin alone, but this difference did not reach statistical significance. This antibiotic combination prevented microbiological failure and complicated bacteremia, but it was more often associated with adverse events